{"symbol":"FBXO5","synonyms":["EMI1","FBX5","Fbxo31"],"name":"F-box protein 5","description":"This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]","ncbiEntrezGeneId":26271,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/26271","proteins":[{"symbol":"FBX5_HUMAN","href":"/api/1.0/protein/FBX5_HUMAN"}],"hgncRootFamilies":[{"name":"F-boxes (FBX)","href":"/api/1.0/gene_family/F-boxes+%28FBX%29"}]}