{"symbol":"FBXO6","synonyms":["FBG2","FBS2","FBX6","FBX6B"],"name":"F-box protein 6","description":"This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":26270,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/26270","proteins":[{"symbol":"FBX6_HUMAN","href":"/api/1.0/protein/FBX6_HUMAN"}],"hgncRootFamilies":[{"name":"F-boxes (FBX)","href":"/api/1.0/gene_family/F-boxes+%28FBX%29"}]}