{"symbol":"FBXO7","synonyms":["FBX","FBX07","FBX7","PARK15","PKPS"],"name":"F-box protein 7","description":"This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":25793,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/25793","proteins":[{"symbol":"FBX7_HUMAN","href":"/api/1.0/protein/FBX7_HUMAN"}],"hgncRootFamilies":[{"name":"F-boxes (FBX)","href":"/api/1.0/gene_family/F-boxes+%28FBX%29"},{"name":"Parkinson disease associated genes (PARK)","href":"/api/1.0/gene_family/Parkinson+disease+associated+genes+%28PARK%29"}]}