{"symbol":"FBXW12","synonyms":["FBXO12","FBXO35","FBW12"],"name":"F-box and WD repeat domain containing 12","description":"Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]","ncbiEntrezGeneId":285231,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/285231","proteins":[{"symbol":"FBW12_HUMAN","href":"/api/1.0/protein/FBW12_HUMAN"}],"hgncRootFamilies":[{"name":"F-boxes (FBX)","href":"/api/1.0/gene_family/F-boxes+%28FBX%29"},{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"}]}