{"symbol":"FGD2","synonyms":["ZFYVE4"],"name":"FYVE, RhoGEF and PH domain containing 2","description":"The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system. [provided by RefSeq, Oct 2016]","ncbiEntrezGeneId":221472,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/221472","proteins":[{"symbol":"FGD2_HUMAN","href":"/api/1.0/protein/FGD2_HUMAN"}],"hgncRootFamilies":[{"name":"Rho guanine nucleotide exchange factors (ARHGEF)","href":"/api/1.0/gene_family/Rho+guanine+nucleotide+exchange+factors+%28ARHGEF%29"},{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}