{"symbol":"FGR","synonyms":["P55-FGR","C-SRC2","SRC2","C-FGR","P55C-FGR","P58-FGR","P58C-FGR"],"name":"FGR proto-oncogene, Src family tyrosine kinase","description":"This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":2268,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2268","proteins":[{"symbol":"FGR_HUMAN","href":"/api/1.0/protein/FGR_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}