{"symbol":"FMOD","synonyms":["SLRR2E","FM"],"name":"fibromodulin","description":"Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]","ncbiEntrezGeneId":2331,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2331","proteins":[{"symbol":"FMOD_HUMAN","href":"/api/1.0/protein/FMOD_HUMAN"}],"hgncRootFamilies":[{"name":"Proteoglycans","href":"/api/1.0/gene_family/Proteoglycans"}]}