{"symbol":"FOXN1","synonyms":["FKHL20","RONU","WHN"],"name":"forkhead box N1","description":"Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5\u0027 UTR of this gene has been observed. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8456,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8456","proteins":[{"symbol":"FOXN1_HUMAN","href":"/api/1.0/protein/FOXN1_HUMAN"}],"hgncRootFamilies":[{"name":"Forkhead boxes (FOX)","href":"/api/1.0/gene_family/Forkhead+boxes+%28FOX%29"}]}