{"symbol":"FPGS","synonyms":[],"name":"folylpolyglutamate synthase","description":"This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]","ncbiEntrezGeneId":2356,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2356","proteins":[{"symbol":"FOLC_HUMAN","href":"/api/1.0/protein/FOLC_HUMAN"}],"hgncRootFamilies":[]}