{"symbol":"FRMPD2","synonyms":["PDZK5C","PDZD5C"],"name":"FERM and PDZ domain containing 2","description":"This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009]","ncbiEntrezGeneId":143162,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/143162","proteins":[{"symbol":"FRPD2_HUMAN","href":"/api/1.0/protein/FRPD2_HUMAN"}],"hgncRootFamilies":[]}