{"symbol":"FXYD4","synonyms":["CHIF"],"name":"FXYD domain containing ion transport regulator 4","description":"This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010]","ncbiEntrezGeneId":53828,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/53828","proteins":[{"symbol":"FXYD4_HUMAN","href":"/api/1.0/protein/FXYD4_HUMAN"}],"hgncRootFamilies":[]}