{"symbol":"FZD4","synonyms":["FZ4","FZE4","FZD4S","CD344","FZ-4","HFZ4"],"name":"frizzled class receptor 4","description":"This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8322,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8322","proteins":[{"symbol":"FZD4_HUMAN","href":"/api/1.0/protein/FZD4_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}