{"symbol":"FZD6","synonyms":["FZ-6","HFZ6","FZ6","NDNC10"],"name":"frizzled class receptor 6","description":"This gene represents a member of the \u0027frizzled\u0027 gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":8323,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8323","proteins":[{"symbol":"FZD6_HUMAN","href":"/api/1.0/protein/FZD6_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}