{"symbol":"FZD7","synonyms":["FZE3"],"name":"frizzled class receptor 7","description":" Members of the \u0027frizzled\u0027 gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif.  FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8324,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8324","proteins":[{"symbol":"FZD7_HUMAN","href":"/api/1.0/protein/FZD7_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}