{"symbol":"FZD8","synonyms":["FZ-8","HFZ8"],"name":"frizzled class receptor 8","description":"This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8325,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8325","proteins":[{"symbol":"FZD8_HUMAN","href":"/api/1.0/protein/FZD8_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}