{"symbol":"GABBR2","synonyms":["NDPLHS","GPRC3B","GABABR2","GPR51","HRIHFB2099","EIEE59","HG20"],"name":"gamma-aminobutyric acid (GABA) B receptor, 2","description":"The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]","ncbiEntrezGeneId":9568,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9568","proteins":[{"symbol":"GABR2_HUMAN","href":"/api/1.0/protein/GABR2_HUMAN"}],"hgncRootFamilies":[{"name":"Gamma-aminobutyric acid (GABA) receptors","href":"/api/1.0/gene_family/Gamma-aminobutyric+acid+%28GABA%29+receptors"},{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}