{"symbol":"GABRG3","synonyms":[],"name":"gamma-aminobutyric acid (GABA) A receptor, gamma 3","description":"This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]","ncbiEntrezGeneId":2567,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2567","proteins":[{"symbol":"GBRG3_HUMAN","href":"/api/1.0/protein/GBRG3_HUMAN"}],"hgncRootFamilies":[{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"},{"name":"Gamma-aminobutyric acid (GABA) receptors","href":"/api/1.0/gene_family/Gamma-aminobutyric+acid+%28GABA%29+receptors"}]}