{"symbol":"GAD2","synonyms":["GAD65"],"name":"glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)","description":"This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]","ncbiEntrezGeneId":2572,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2572","proteins":[{"symbol":"DCE2_HUMAN","href":"/api/1.0/protein/DCE2_HUMAN"}],"hgncRootFamilies":[]}