{"symbol":"GADD45A","synonyms":["DDIT1","GADD45"],"name":"growth arrest and DNA-damage-inducible, alpha","description":"This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]","ncbiEntrezGeneId":1647,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1647","proteins":[{"symbol":"GA45A_HUMAN","href":"/api/1.0/protein/GA45A_HUMAN"}],"hgncRootFamilies":[]}