{"symbol":"GAN","synonyms":["KLHL16","GAN1"],"name":"gigaxonin","description":"This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). [provided by RefSeq, Oct 2008]","ncbiEntrezGeneId":8139,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8139","proteins":[{"symbol":"GAN_HUMAN","href":"/api/1.0/protein/GAN_HUMAN"}],"hgncRootFamilies":[{"name":"BTB (POZ) domain containing (BTBD)","href":"/api/1.0/gene_family/BTB+%28POZ%29+domain+containing+%28BTBD%29"},{"name":"Kelch-like (KLHL)","href":"/api/1.0/gene_family/Kelch-like+%28KLHL%29"}]}