{"symbol":"GCLC","synonyms":["GLCL","GLCLC"],"name":"glutamate-cysteine ligase, catalytic subunit","description":"Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]","ncbiEntrezGeneId":2729,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2729","proteins":[{"symbol":"GSH1_HUMAN","href":"/api/1.0/protein/GSH1_HUMAN"}],"hgncRootFamilies":[]}