{"symbol":"GCLM","synonyms":["GLCLR"],"name":"glutamate-cysteine ligase, modifier subunit","description":"Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]","ncbiEntrezGeneId":2730,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2730","proteins":[{"symbol":"GSH0_HUMAN","href":"/api/1.0/protein/GSH0_HUMAN"}],"hgncRootFamilies":[]}