{"symbol":"GDF10","synonyms":["BMP-3B","BMP3B"],"name":"growth differentiation factor 10","description":"This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016]","ncbiEntrezGeneId":2662,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2662","proteins":[{"symbol":"BMP3B_HUMAN","href":"/api/1.0/protein/BMP3B_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}