{"symbol":"GDF2","synonyms":["BMP-9","HHT5","BMP9"],"name":"growth differentiation factor 2","description":"This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jul 2016]","ncbiEntrezGeneId":2658,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2658","proteins":[{"symbol":"GDF2_HUMAN","href":"/api/1.0/protein/GDF2_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}