{"symbol":"GDF3","synonyms":["MCOPCB6","KFS3","MCOP7"],"name":"growth differentiation factor 3","description":"This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients. [provided by RefSeq, Aug 2016]","ncbiEntrezGeneId":9573,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9573","proteins":[{"symbol":"GDF3_HUMAN","href":"/api/1.0/protein/GDF3_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}