{"symbol":"GGCX","synonyms":["VKCFD1"],"name":"gamma-glutamyl carboxylase","description":"This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]","ncbiEntrezGeneId":2677,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2677","proteins":[{"symbol":"VKGC_HUMAN","href":"/api/1.0/protein/VKGC_HUMAN"}],"hgncRootFamilies":[]}