{"symbol":"GLDC","synonyms":["GCSP","HYGN1"],"name":"glycine dehydrogenase (decarboxylating)","description":"Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]","ncbiEntrezGeneId":2731,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2731","proteins":[{"symbol":"GCSP_HUMAN","href":"/api/1.0/protein/GCSP_HUMAN"}],"hgncRootFamilies":[]}