{"symbol":"GLRX","synonyms":["GRX","GRX1"],"name":"glutaredoxin (thioltransferase)","description":"This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer\u0027s disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":2745,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2745","proteins":[{"symbol":"GLRX1_HUMAN","href":"/api/1.0/protein/GLRX1_HUMAN"}],"hgncRootFamilies":[]}