{"symbol":"GMDS","synonyms":["SDR3E1","GMD"],"name":"GDP-mannose 4,6-dehydratase","description":"GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]","ncbiEntrezGeneId":2762,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2762","proteins":[{"symbol":"GMDS_HUMAN","href":"/api/1.0/protein/GMDS_HUMAN"}],"hgncRootFamilies":[{"name":"Short chain dehydrogenase/reductase superfamily (SDR)","href":"/api/1.0/gene_family/Short+chain+dehydrogenase%24slash%24reductase+superfamily+%28SDR%29"}]}