{"symbol":"GNA11","synonyms":["GNA-11","FHH2","FBH2","FBH","HYPOC2","HHC2"],"name":"guanine nucleotide binding protein (G protein), alpha 11 (Gq class)","description":"The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]","ncbiEntrezGeneId":2767,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2767","proteins":[{"symbol":"GNA11_HUMAN","href":"/api/1.0/protein/GNA11_HUMAN"}],"hgncRootFamilies":[]}