{"symbol":"GPD1","synonyms":["GPD-C","GPDH-C","HTGTI"],"name":"glycerol-3-phosphate dehydrogenase 1 (soluble)","description":"This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]","ncbiEntrezGeneId":2819,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2819","proteins":[{"symbol":"GPDA_HUMAN","href":"/api/1.0/protein/GPDA_HUMAN"}],"hgncRootFamilies":[]}