{"symbol":"GPI","synonyms":["GNPI","SA-36","NLK","PHI","SA36","AMF"],"name":"glucose-6-phosphate isomerase","description":"This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]","ncbiEntrezGeneId":2821,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2821","proteins":[{"symbol":"G6PI_HUMAN","href":"/api/1.0/protein/G6PI_HUMAN"}],"hgncRootFamilies":[]}