{"symbol":"GPR151","synonyms":["PGR7","GALR4","GPCR-2037","GALRL"],"name":"G protein-coupled receptor 151","description":"This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]","ncbiEntrezGeneId":134391,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/134391","proteins":[{"symbol":"GP151_HUMAN","href":"/api/1.0/protein/GP151_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}