{"symbol":"GPS2","synonyms":["AMF-1"],"name":"G protein pathway suppressor 2","description":"This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":2874,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2874","proteins":[{"symbol":"GPS2_HUMAN","href":"/api/1.0/protein/GPS2_HUMAN"}],"hgncRootFamilies":[]}