{"symbol":"GPT","synonyms":["AAT1","ALT1","GPT1"],"name":"glutamic-pyruvate transaminase (alanine aminotransferase)","description":"This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]","ncbiEntrezGeneId":2875,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2875","proteins":[{"symbol":"ALAT1_HUMAN","href":"/api/1.0/protein/ALAT1_HUMAN"}],"hgncRootFamilies":[]}