{"symbol":"GPT2","synonyms":["ALT2","MRT49","GPT 2"],"name":"glutamic pyruvate transaminase (alanine aminotransferase) 2","description":"This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]","ncbiEntrezGeneId":84706,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/84706","proteins":[{"symbol":"ALAT2_HUMAN","href":"/api/1.0/protein/ALAT2_HUMAN"}],"hgncRootFamilies":[]}