{"symbol":"GRIA4","synonyms":["GLURD","GLUR4","GLUR4C","NEDSGA","GLUA4"],"name":"glutamate receptor, ionotropic, AMPA 4","description":"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA-\u003eGGA; R-\u003eG). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":2893,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2893","proteins":[{"symbol":"GRIA4_HUMAN","href":"/api/1.0/protein/GRIA4_HUMAN"}],"hgncRootFamilies":[{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"},{"name":"Glutamate receptors","href":"/api/1.0/gene_family/Glutamate+receptors"}]}