{"symbol":"GRIK1","synonyms":["GLUK1","GLUR5","EAA3","gluR-5","EEA3","GLR5"],"name":"glutamate receptor, ionotropic, kainate 1","description":"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG-\u003eCGG; Q-\u003eR) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":2897,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2897","proteins":[{"symbol":"GRIK1_HUMAN","href":"/api/1.0/protein/GRIK1_HUMAN"}],"hgncRootFamilies":[{"name":"Glutamate receptors","href":"/api/1.0/gene_family/Glutamate+receptors"},{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"}]}