{"symbol":"GRPR","synonyms":["BB2","BB2R"],"name":"gastrin-releasing peptide receptor","description":"Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":2925,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2925","proteins":[{"symbol":"GRPR_HUMAN","href":"/api/1.0/protein/GRPR_HUMAN"}],"hgncRootFamilies":[{"name":"Bombesin receptors","href":"/api/1.0/gene_family/Bombesin+receptors"}]}