{"symbol":"GTF3A","synonyms":["TFIIIA"],"name":"general transcription factor IIIA","description":"The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":2971,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2971","proteins":[{"symbol":"TF3A_HUMAN","href":"/api/1.0/protein/TF3A_HUMAN"}],"hgncRootFamilies":[{"name":"General transcription factors (GTF)","href":"/api/1.0/gene_family/General+transcription+factors+%28GTF%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}