{"symbol":"GTF3C6","synonyms":["C6ORF51","BA397G5.3","TFIIIC35"],"name":"general transcription factor IIIC, polypeptide 6, alpha 35kDa","description":"RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.[supplied by OMIM, Mar 2008]","ncbiEntrezGeneId":112495,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/112495","proteins":[{"symbol":"TF3C6_HUMAN","href":"/api/1.0/protein/TF3C6_HUMAN"}],"hgncRootFamilies":[{"name":"General transcription factors (GTF)","href":"/api/1.0/gene_family/General+transcription+factors+%28GTF%29"}]}