{"symbol":"GUCY2C","synonyms":["GUC2C","GC-C","STAR","DIAR6","MECIL","MUCIL"],"name":"guanylate cyclase 2C","description":"This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive). [provided by RefSeq, Nov 2016]","ncbiEntrezGeneId":2984,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2984","proteins":[{"symbol":"GUC2C_HUMAN","href":"/api/1.0/protein/GUC2C_HUMAN"}],"hgncRootFamilies":[{"name":"Guanylate cyclases (GUCY)","href":"/api/1.0/gene_family/Guanylate+cyclases+%28GUCY%29"},{"name":"Receptor kinases","href":"/api/1.0/gene_family/Receptor+kinases"}]}