{"symbol":"GYPB","synonyms":["CD235B","GPB","GYPA","GYP","PAS-3"],"name":"glycophorin B (MNS blood group)","description":"Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5\u0027 UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]","ncbiEntrezGeneId":2994,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2994","proteins":[{"symbol":"GLPB_HUMAN","href":"/api/1.0/protein/GLPB_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Blood group antigens","href":"/api/1.0/gene_family/Blood+group+antigens"}]}