{"symbol":"H2AFJ","synonyms":["H2AJ"],"name":"H2A histone family, member J","description":"Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. This gene also encodes an antimicrobial peptide with antibacterial and antifungal activity.[provided by RefSeq, Oct 2015]","ncbiEntrezGeneId":55766,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55766","proteins":[{"symbol":"H2AJ_HUMAN","href":"/api/1.0/protein/H2AJ_HUMAN"}],"hgncRootFamilies":[{"name":"Histones","href":"/api/1.0/gene_family/Histones"}]}