{"symbol":"H2AFY","synonyms":["MACROH2A1.2","MACROH2A1.1","H2AF12M","H2A.Y","H2A/Y","MH2A1"],"name":"H2A histone family, member Y","description":"Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]","ncbiEntrezGeneId":9555,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9555","proteins":[{"symbol":"H2AY_HUMAN","href":"/api/1.0/protein/H2AY_HUMAN"}],"hgncRootFamilies":[{"name":"Histones","href":"/api/1.0/gene_family/Histones"}]}