{"symbol":"HACE1","synonyms":["SPPRS"],"name":"HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1","description":"This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm\u0027s tumor. [provided by RefSeq, Mar 2016]","ncbiEntrezGeneId":57531,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/57531","proteins":[{"symbol":"HACE1_HUMAN","href":"/api/1.0/protein/HACE1_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"}]}