{"symbol":"HAVCR2","synonyms":["HAVCR-2","TIMD3","TIMD-3","TIM-3","KIM-3","TIM3","CD366"],"name":"hepatitis A virus cellular receptor 2","description":"The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]","ncbiEntrezGeneId":84868,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/84868","proteins":[{"symbol":"HAVR2_HUMAN","href":"/api/1.0/protein/HAVR2_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}