{"symbol":"HCST","synonyms":["DAP10","KAP10","PIK3AP"],"name":"hematopoietic cell signal transducer","description":"This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10870,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10870","proteins":[{"symbol":"HCST_HUMAN","href":"/api/1.0/protein/HCST_HUMAN"}],"hgncRootFamilies":[]}