{"symbol":"HDAC1","synonyms":["RPD3","HD1","RPD3L1","GON-10"],"name":"histone deacetylase 1","description":"Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":3065,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3065","proteins":[{"symbol":"HDAC1_HUMAN","href":"/api/1.0/protein/HDAC1_HUMAN"}],"hgncRootFamilies":[]}