{"symbol":"HDAC3","synonyms":["RPD3-2","HD3"],"name":"histone deacetylase 3","description":"Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8841,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8841","proteins":[{"symbol":"HDAC3_HUMAN","href":"/api/1.0/protein/HDAC3_HUMAN"}],"hgncRootFamilies":[]}